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Invitrogen™ MEI1 Polyclonal Antibody
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Catalog No. PIPA561916
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100 μL
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PIPA561916 100 μL
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Catalog No. PIPA561916 Supplier Invitrogen™ Supplier No. PA561916
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HMKEKFSKKL ASSSFIRLTL ELKARFCSGL SHSALNQVCS NFLYYMCLNL LSAPEKTGPP SKEELSAVSE LLQHGLPQIS SRS Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 81%.

The predominant cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse. MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274 amino acid protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis. With predominant expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility. Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest. Human MEI1 shares 79% sequence similarity with its mouse homolog. There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEI1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MEI1
Gene Accession No. Q5TIA1
Gene Alias 4932408F18Rik; MEI1; meiosis defective 1; meiosis defective protein 1; meiosis inhibitor 1; meiosis inhibitor protein 1; meiotic double-stranded break formation protein 1; SPATA38; spermatogenesis associated 38
Gene Symbols MEI1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MEI1. Recombinant protein control fragment (Product #RP-95369).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 150365
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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