MEI1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8758	Proteintech Group Inc 134561AP150UL	150 μL

Description

This antibody recognizes isoform 1, 2, 3, 5, and 7 of MEI1 gene with MW 141 kDa, 67-72 kDa, 49-54 kDa, and 26 kDa.

The predomit cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse. MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274 amino acid protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis. With predomit expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility. Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest. Human MEI1 shares 79% sequence similarity with its mouse homolog. There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.

Specifications

• Antigen: MEI1
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q5TIA1, Q9D4I2
• Gene ID (Entrez): 150365, 315162, 74369
• Immunogen: MEI1 Fusion Protein Ag4253
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MEI1

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: MEI1, Meiosis defective protein 1, meiosis inhibitor 1, Meiosis inhibitor protein 1
• Gene Symbols: MEI1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody