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Melan-A/MART-1 Antibody (A103 + M2-7C10 + M2-9E3), Alexa Fluor™ 532, Novus Biologicals™
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Catalog No. NP23446A32 Shop All R&D Systems Products
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NP23446A32 0.1 mL
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Catalog No. NP23446A32 Supplier Novus Biologicals Supplier No. NBP234546AF532
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Description

Mouse Monoclonal Antibody

Melan-A/MART-1 Monoclonal specifically detects Melan-A/MART-1 in Human, Mouse, Rat, Canine samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Flow (Intracellular).

Specifications

Antigen Melan-A/MART-1
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone A103 + M2-7C10 + M2-9E3
Conjugate Alexa Fluor 532
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular)
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias Antigen LB39-AA, Antigen SK29-AA, Mart 1 Melan A, MART1MART-1, melan-A, melanoma antigen recognized by T-cells 1, Protein Melan-A
Gene Symbols MLANA
Host Species Mouse
Immunogen Recombinant full-length hMelan-A/MART-1 protein (A103; M2-7C10; M2-9E3) (Uniprot: Q16655)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cytoskeleton Markers, Immunology
Primary or Secondary Primary
Gene ID (Entrez) 2315.0
Test Specificity This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This monoclonal antibody cocktail labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
Target Species Human, Mouse, Rat, Canine
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ, IgG2b λ, IgG2b κ
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