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Invitrogen™ Mesothelioma Monoclonal Antibody (ME1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA2310

Catalog No. MA2310


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Description

Description

MA2-310 detects a surface membrane glycoprotein preferentially expressed on normal and malignant mesothelial cells from human tissues. This antibody does not detect most lung adenocarcinoma cell lines, or well and moderately differentiated pulmonary adenocarcinomas. MA2-310 has been successfully used in indirect immunofluorescence, immunocytochemistry, immunohistochemistry and solid-phase radioimmunoassay procedures. This antibody does not react in Western blot procedures. Immunohistochemical staining of sarcomatoid mesotheliomas with MA2-310 results in intense staining of mesothelial cells. It has been reported that this antibody reacts with a 200 kDa surface membrane glycoprotein preferentially expressed on normal and malignant mesothelial cells, but does not react with most lung adenocarcinoma cell lines, or well and moderately differentiated pulmonary adenocarcinomas. In studies, this antibody was shown to react with all mesotheliomas examined, with 50%-99% of cells of both pleural and peritoneal mesotheliomas stained. Literature reports have indicated that the antibody does not bind with many common breast (MCF-7, T47D, ZR75-1, BT20, SJC38), ovarian (OVCA429, OVCA432, OVCA434), colon (SW480, SW620, CX1, WIDR, Co112), and renal-cell (FOHN, ZNH1) carcinoma cell lines, nor with several leukemia (K562, U937, CEM) or fibroblast (WI38, R2F) cell lines. Some reactivity has been reported with some pulmonary tumors of squamous-cell and small-cell carcinoma origin, adenocarcino...

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Mesothelioma
Monoclonal
0.5 mg/mL
PBS with 0.05% sodium azide
Mesothelioma cell line SPC111.
25 μg
Primary
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunohistochemistry, Radioimmune Assays (RIA), Immunocytochemistry
ME1
Unconjugated
Mouse
Protein A
RUO
Human
Antibody
IgG1
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