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Invitrogen™ Mesothelioma Monoclonal Antibody (ME1)
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Catalog No. MA2310
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25 μg
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MA2310 25 μg
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Catalog No. MA2310 Supplier Invitrogen™ Supplier No. MA2310
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Description

Mouse Monoclonal Antibody

MA2-310 detects a surface membrane glycoprotein preferentially expressed on normal and malignant mesothelial cells from human tissues. This antibody does not detect most lung adenocarcinoma cell lines, or well and moderately differentiated pulmonary adenocarcinomas. MA2-310 has been successfully used in indirect immunofluorescence, immunocytochemistry, immunohistochemistry and solid-phase radioimmunoassay procedures. This antibody does not react in Western blot procedures. Immunohistochemical staining of sarcomatoid mesotheliomas with MA2-310 results in intense staining of mesothelial cells. It has been reported that this antibody reacts with a 200 kDa surface membrane glycoprotein preferentially expressed on normal and malignant mesothelial cells, but does not react with most lung adenocarcinoma cell lines, or well and moderately differentiated pulmonary adenocarcinomas. In studies, this antibody was shown to react with all mesotheliomas examined, with 50%-99% of cells of both pleural and peritoneal mesotheliomas stained. Literature reports have indicated that the antibody does not bind with many common breast (MCF-7, T47D, ZR75-1, BT20, SJC38), ovarian (OVCA429, OVCA432, OVCA434), colon (SW480, SW620, CX1, WIDR, Co112), and renal-cell (FOHN, ZNH1) carcinoma cell lines, nor with several leukemia (K562, U937, CEM) or fibroblast (WI38, R2F) cell lines. Some reactivity has been reported with some pulmonary tumors of squamous-cell and small-cell carcinoma origin, adenocarcino...

TRUSTED_SUSTAINABILITY

Specifications

Antigen Mesothelioma
Applications Immunohistochemistry, Radioimmune Assays (RIA), Immunocytochemistry
Classification Monoclonal
Clone ME1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Host Species Mouse
Immunogen Mesothelioma cell line SPC111.
Purification Method Protein A
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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