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MITF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7205297 Shop All Proteintech Group Inc Products
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50-172-8482 150 μL
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Catalog No. 50-172-8482 Supplier Proteintech Group Inc Supplier No. 130921AP150UL
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Description

Rabbit Polyclonal Antibody

Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5′-CACGTG-3′) found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigmant epithelium. This protein is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrom type 2 and Tietz syndrome. Alternateively spliced transcript variants encoding different isoforms have been identified.

Specifications

Antigen MITF
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.21 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MITF
Gene Accession No. O75030, O88368, Q08874
Gene Alias bHLHe32, MI, MITF, WS2A
Gene Symbols Mitf
Host Species Rabbit
Immunogen MITF Fusion Protein Ag3679
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17342, 25094, 4286
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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