MITF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8482	Proteintech Group Inc 130921AP150UL	150 μL

Description

Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5′-CACGTG-3′) found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigmant epithelium. This protein is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrom type 2 and Tietz syndrome. Alternateively spliced transcript variants encoding different isoforms have been identified.

Specifications

• Antigen: MITF
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O75030, O88368, Q08874
• Gene ID (Entrez): 17342, 25094, 4286
• Immunogen: MITF Fusion Protein Ag3679
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MITF

• Concentration: 0.21 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: bHLHe32, MI, MITF, WS2A
• Gene Symbols: Mitf
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody