Tocris™ ML 00253764 hydrochloride

Melanocortin MC4 receptor antagonist; brain penetrant

Manufacturer: Tocris™ 4854/50

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Catalog No. 48-545-0

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For Research Use Only


    Product Type ML 00253764 hydrochloride
    Inhibitors ML 00253764 hydrochloride
    Purity >98
    Molecular Weight 413.71
    Quantity 50mg

    Non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 0.32, 0.81 and 2.12µM for MC4, MC3 and MC5 receptors respectively). Decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor. Increases food intake and reduces loss of lean body mass in tumor bearing mice. Brain penetrant.

    • Chemical Name: 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride
    • Formula: C18H18BrFN2O.HCl
    • Solubility: Soluble to 10mM in water and to 100mM in DMSO
    • Purity: >98

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