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ML 218 hydrochloride, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.
Specifications
Quantity | 10 mg |
Formula Weight | 405.79 |
Percent Purity | >99% |
Chemical Name or Material | ML 218 hydrochloride |
Safety and Handling
Recommended Storage | Store at +4°C |
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