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  5. Tocris Bioscience™ ML 218 hydrochloride

Tocris Bioscience™ ML 218 hydrochloride
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Catalog No. 450710
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Catalog No. Quantity
45-071-0 10 mg
45-075-0 50 mg
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Catalog No. 45-071-0 Supplier Tocris Bioscience™ Supplier No. 4507/10
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Description

CaV3.x blocker

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Chemical Identifiers

CAS 2319922-08-0
Molecular Formula C19H27Cl3N2O

Specifications

Quantity 10 mg
Formula Weight 405.79
Purity >99%
Molecular Weight (g/mol) 405.788
Chemical Name or Material ML 218 hydrochloride

Safety and Handling

Recommended Storage Store at +4°C
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