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  8. ML 221, Tocris Bioscience™

ML 221, Tocris Bioscience™

Catalog Number p-4816798
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
877636-42-5
C17H11N3O6S
385.35
UASIRTUMPRQVFY-UHFFFAOYSA-N
4-oxo-6-pyrimidin-2-ylsulfanylmethyl pyran-3-yl 4-nitrobenzoate, 4-oxo-6-pyrimidin-2-ylthio methyl-4h-pyran-3-yl 4-nitrobenzoate, d05nxx, 4-oxo-6-pyrimidin-2-ylsulfanyl methyl pyran-3-yl 4-nitrobenzoate, 5-4-nitrobenzoyl oxy-2-2-pyrimidinylthio methyl-4h-pyran-4-one
7217941
[4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
This item is not returnable. View return policy
877636-42-5
C17H11N3O6S
385.35
UASIRTUMPRQVFY-UHFFFAOYSA-N
4-oxo-6-pyrimidin-2-ylsulfanylmethyl pyran-3-yl 4-nitrobenzoate, 4-oxo-6-pyrimidin-2-ylthio methyl-4h-pyran-3-yl 4-nitrobenzoate, d05nxx, 4-oxo-6-pyrimidin-2-ylsulfanyl methyl pyran-3-yl 4-nitrobenzoate, 5-4-nitrobenzoyl oxy-2-2-pyrimidinylthio methyl-4h-pyran-4-one
7217941
[4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

Description

Apelin antagonist

Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.
Quantity 10 mg
Formula Weight 385.35
Percent Purity >99%
Chemical Name or Material ML 221

Safety and Handling

Recommended Storage Store at +4°C
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