Tocris™ ML 240

ATP-competitive inhibitor of p97 ATPase

Manufacturer: Tocris™ 5153/50

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Catalog No. 51-535-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type ML 240
    Inhibitors ML 240
    Purity >99
    Molecular Weight 396.44
    Quantity 50mg

    ATP-competitive inhibitor of p97 ATPase (IC50 = 110nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

    • Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
    • Formula: C23H20N6O
    • CAS Number: 1346527-98-7
    • Solubility: Soluble to 20mM in DMSO
    • Purity: >99

  • Description & Specifications

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