Tocris ML 240
ATP-competitive inhibitor of p97 ATPase
Manufacturer: Tocris 5153/10
DescriptionATP-competitive inhibitor of p97 ATPase (IC50 = 110nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
- Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
- Formula: C23H20N6O
- CAS Number: 1346527-98-7
- Solubility: Soluble to 20mM in DMSO
- Purity: >99
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