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  5. Tocris Bioscience™ ML 240

Tocris Bioscience™ ML 240
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Catalog No. 515310
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

ATP-competitive inhibitor of p97 ATPase

ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

Specifications

Quantity 10 mg
Product Type ML 240
Purity >99%
Molecular Weight (g/mol) 396.44
Inhibitors ML 240

For Research Use Only

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