Tocris ML 337
Selective negative allosteric modulator of mGlu3
Manufacturer: Tocris 4982/10
DescriptionSelective negative allosteric modulator of mGlu3 (IC50 = 593nM). Displays no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30µM. Brain penetrant.
- Chemical Name: [2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone
- Formula: C21H20FNO3
- CAS Number: 1443118-44-2
- Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
- Purity: >98
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