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Invitrogen™ MLK1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA529827
Description
Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji, Jurkat, Raji, NCI-H929. Predicted reactivity: Mouse (99%), Rat (97%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Specifications
MLK1 | |
Polyclonal | |
Unconjugated | |
MAP3K9 | |
E130314H24Rik; Map3k9; MEKK9; mitogen activated protein kinase kinase kinase 9; mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); mixed-lineage kinase 1; MLK1; Prke1; RGD1562149 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
4293 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
0.4 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
P80192 | |
MAP3K9 | |
Recombinant fragment corresponding to a region within amino acids 198 and 433 of Human MLK1. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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