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Invitrogen™ MLK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529827

Catalog No. PIPA529827


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Description

Description

Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji, Jurkat, Raji, NCI-H929. Predicted reactivity: Mouse (99%), Rat (97%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MLK1
Polyclonal
Unconjugated
MAP3K9
E130314H24Rik; Map3k9; MEKK9; mitogen activated protein kinase kinase kinase 9; mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); mixed-lineage kinase 1; MLK1; Prke1; RGD1562149
Rabbit
Antigen affinity chromatography
RUO
4293
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot, Immunocytochemistry
0.4 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P80192
MAP3K9
Recombinant fragment corresponding to a region within amino acids 198 and 433 of Human MLK1.
100 μL
Primary
Human
Antibody
IgG
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