Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MLL / HRX Polyclonal Antibody, Active Motif™
SDP

Rabbit Polyclonal Antibody

$156.65 - $638.65

Specifications

Antigen MLL / HRX
Concentration Lot-Specific
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Conjugate Unconjugated
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3312
SDP
Encompass
View Documents
Active Motif
61296
10 μg
Each for $156.65
Only null left
Add to Cart
 
50-199-3311
SDP
Encompass
View Documents
Active Motif
61295
100 μg
Each for $638.65
Only null left
Add to Cart
 
Description

Description

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
Specifications

Specifications

MLL / HRX
ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunofluorescence
Unconjugated
Rabbit
Human, Mouse
P55200, Q03164
214162, 4297
This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.
Primary
-20°C, Avoid Freeze/Thaw Cycles
KMT2A
Lot-Specific
Polyclonal
Liquid
RUO
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
ALL1; ALL-1; CDK6/MLL fusion protein; C-terminal cleavage product of 180 kDa; CXXC7; CXXC-type zinc finger protein 7; Histone-lysine N-methyltransferase 2A; HRX; HTRX; HTRX1; KMT2A; lysine (K)-specific methyltransferase 2A; lysine methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL; MLL cleavage product C180; MLL cleavage product N320; MLL/ENL fusion protein; MLL/GAS7; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; MLL1; MLL1A; MLL-AF4 der(11) fusion protein; MLL-AF9; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 1; N-terminal cleavage product of 320 kDa; p180; p320; rearranged MLL protein; TET1-MLL; Trithorax-like protein; TRX1; WDSTS; Zinc finger protein HRX
KMT2A
IgG
Protein A
Antibody
Videos
SDS
Documents

Documents

Product Certifications
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.