MLL1 Recombinant Rabbit Monoclonal Antibody (BL-175-7E8), Bethyl Laboratories

Rabbit Recombit Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-157-1274	Bethyl Laboratories, Inc A700010T	20 μL
50-157-1273	Bethyl Laboratories, Inc A700010	100 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

Specifications

• Antigen: MLL1
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q03164
• Gene ID (Entrez): 4297
• Immunogen: Between 720 and 780
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: KMT2A

• Clone: BL-175-7E8
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: BBS with 0.09% sodium azide; pH 8.2
• Gene Alias: ALL-1; Trithorax-like protein
• Gene Symbols: KMT2A
• Isotype: IgG
• Purification Method: Ion-exchange chromatography
• Product Type: Antibody