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  5. Tocris Bioscience™ MNI-caged-L-glutamate

Tocris Bioscience™ MNI-caged-L-glutamate
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Catalog No. 149050
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14-905-0 50 mg
14-901-0 10 mg
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Catalog No. 14-905-0 Supplier Tocris Bioscience™ Supplier No. 1490/50
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Description

Stable photoreleaser of L-glutamate

MNI-caged-L-glutamate is a form of glutamate linked to a photo-protecting group, 4-methoxy-7-nitroindolinyl (MNI); it rapidly and efficiently releases L-glutamate (Cat. No. 0218) by photolysis (300 - 380 nm excitation) with a quantum yield in the 0.065-0.085 range. It is also suitable for use with two-photon uncaging microscopy (cross-section of 0.06 GM at 730 nm). MNI-caged-L-glutamate is optically compatible with other chromophores used for fluorescence imaging, such as GFP, YFP and most Ca2+ dyes. MNI-caged-L-glutamate is 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate. MNI-caged-L-glutamate is water-soluble, stable at neutral pH, highly resistant to hydrolysis and pharmacologically inactive at neuronal glutamate receptors and transporters (up to mM concentrations). MNI-caged-L-glutamate can be used for in situ studies of fast synaptic glutamate receptors.

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Chemical Identifiers

CAS 295325-62-1
Molecular Formula C14H17N3O6

Specifications

Quantity 50 mg
Formula Weight 323.3
Purity >98%
Molecular Weight (g/mol) 323.305
Chemical Name or Material MNI-caged-L-glutamate

Safety and Handling

Recommended Storage Store at -20°C
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