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MilliporeSigma™ Mouse anti-CREB (Ascites Free), Clone: LB9,

Catalog No. MAB5432C Shop All MilliporeSigma Products
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MAB5432C 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects CREB (Ascites Free) clone: LB9 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation on by various kinases, including PKA and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CREB (Ascites Free)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone LB9
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P16220
Gene Symbols CREB1
Host Species Mouse
Immunogen Recombinant CREB-A protein.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_604391
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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