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Mouse anti-Cytokeratin, HMW, Clone: AE3, Azide Free, Novus Biologicals™
SDP

Catalog No. NBP23317002 Shop All R&D Systems Products
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0.2 mg
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NBP23317002 0.2 mg
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Catalog No. NBP23317002 Supplier Novus Biologicals Supplier No. NBP2331700.2MG

Specifications

Antigen Cytokeratin, HMW
Applications Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone AE3
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, ELISA 1-5ug/ml for coating, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml, CyTOF-ready
Formulation 10mM PBS - BSA free with No Preservative
Gene Alias CK-2P, cytokeratin 2, Cytokeratin-2P, HUMCYT2A, K2P, K76, keratin 76, keratin, type II cytoskeletal 2 oral, Keratin-76, KRT2Bcytokeratin-2P, KRT2Pkeratin 2p, KRT76, Type-II keratin Kb9
Gene Symbols KRT76
Host Species Mouse
Immunogen Human epidermal keratin was used as the immunogen for the Cytokeratin HMW AE3 antibody.
Purification Method Protein G purified
Quantity 0.2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51350
Test Specificity This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
Target Species Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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