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Mouse anti-ER beta/NR3A2, Clone: ERb455, Azide Free, Novus Biologicals™
SDP

Catalog No. NBP23306602 Shop All R&D Systems Products
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0.2 mg
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NBP23306602 0.2 mg
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Catalog No. NBP23306602 Supplier Novus Biologicals Supplier No. NBP2330660.2MG

Specifications

Antigen ER beta/NR3A2
Applications Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone ERb455
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Western Blot, ELISA 1-5ug/ml for coating, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
Formulation 10mM PBS - BSA free with No Preservative
Gene Alias Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2
Gene Symbols ESR2
Host Species Mouse
Immunogen A recominant protein fragment specific to Estrogen Receptor beta was used as the immunogen for the ERb455 antibody.
Purification Method Protein G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Breast Cancer, Cancer, Cell Biology, Cell Cycle and Replication, Dendritic Cell Markers, GPCR, Neuroscience, Signal Transduction, Transcription Factors and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 2100
Test Specificity Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Target Species Human, Mouse, Rat, Pig, Equine, Primate, Sheep
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG2a
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