Mouse anti-Pax6, Clone: PAX6/1166, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2445760.02MG
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), ImmunofluorescencePax6 Monoclonal antibody specifically detects Pax6 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Flow (Intracellular), Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein|
|Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuronal Stem Cells, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision|
|Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml|
|keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6|
|Protein A or G purified|
|Store at 4C.|
|Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.|
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