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Mouse anti-Pax6, Clone: PAX6/1166, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2445760.02MG

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Catalog No. NBP24457600


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Pax6 Monoclonal antibody specifically detects Pax6 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Flow (Intracellular), Immunofluorescence.
Specifications

Specifications

Pax6
PAX6/1166
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
PAX6
Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein
47 kDa
0.02 mg
Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuronal Stem Cells, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision
Primary
5080
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
0.2mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
P26367
keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6
Mouse
IgG1 Kappa
Protein A or G purified
RUO
Store at 4C.
Monoclonal
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
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