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  6. Mouse anti-TNF-alpha, Clone: TNF656, Azide Free, Novus Biologicals™

Mouse anti-TNF-alpha, Clone: TNF656, Azide Free, Novus Biologicals™
SDP

Catalog No. NBP23472702 Shop All R&D Systems Products
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0.2 mg
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NBP23472702 0.2 mg
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Catalog No. NBP23472702 Supplier Novus Biologicals Supplier No. NBP2347270.2 MG

Description

Mouse Monoclonal Antibody

TNF-alpha Monoclonal antibody specifically detects TNF-alpha in Human samples. It is validated for ELISA, Functional.

Specifications

Antigen TNF-alpha
Applications ELISA, Functional Assay
Classification Monoclonal
Clone TNF656
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution ELISA 1-5ug/ml for coating, Functional
Formulation 10mM PBS - BSA free with No Preservative
Gene Accession No. P01375
Gene Alias APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Gene Symbols TNF
Host Species Mouse
Immunogen Recombinant human TNF-alpha
Molecular Weight of Antigen 17 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, Asthma, Autophagy, Biologically Active Proteins, Cancer, Cytokine Research, Diabetes Research, Immune System Diseases, Immunology, Innate Immunity
Primary or Secondary Primary
Gene ID (Entrez) 7124
Test Specificity This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Reconstitution Protein A purified
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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