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Mouse anti-Tyrosinase, Clone: T311, Azide Free, Novus Biologicals™
SDP

Catalog No. NBP23316002 Shop All R&D Systems Products
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0.2 mg
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NBP23316002 0.2 mg
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Catalog No. NBP23316002 Supplier Novus Biologicals Supplier No. NBP2331600.2MG

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Specifications

Antigen Tyrosinase
Applications ELISA
Classification Monoclonal
Clone T311
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution ELISA 1-5ug/ml for coating
Formulation 10mM PBS - BSA free with No Preservative
Gene Alias CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Gene Symbols TYR
Host Species Mouse
Immunogen Recombinant tyrosinase protein
Purification Method Protein G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Lipid and Metabolism
Primary or Secondary Primary
Gene ID (Entrez) 7299
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG2a κ
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