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R&D Systems™ Mouse LIF DuoSet ELISA

Catalog No. DY449
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Description

Includes

Capture antibody, detection antibody, recombinant standard, streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP) and development protocols

For the development of sandwich ELISAs to measure natural and recombinant mouse Leukemia Inhibitory Factor (LIF)

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

Specifications

Quantity 1 Kit
Species Mouse
Conjugate Biotin
Binding Target LIF
Assay Range 6.25 to 400 pg/mL
For Use With (Application) ELISA
Gene ID (Entrez) 3976
Synonym CDF, D factor, DIA, differentiation inhibitory activity, differentiation stimulating factor, Differentiation-stimulating factor, Emfilermin, HILDA, HILDAcholinergic differentiation factor, leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor), Melanoma-derived LPL inhibitor, MLPLI
Content And Storage Store the unopened product at 2°C to 8°C. Do not use past expiration date.
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