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  8. MRK 560, Tocris Bioscience™

MRK 560, Tocris Bioscience™

Catalog Number 400010
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
677772-84-8
C19H17ClF5NO4S2
517.91
WDZVWDXOIGQJIO-UHFFFAOYSA-N
n-cis-4-4-chlorophenyl sulfonyl-4-2,5-difluorophenyl cyclohexyl-1,1,1-trifluoromethanesulfonamide, cyclohexyl sulfone-based compound, 32, n-4-4-chlorobenzene sulfonyl-4-2,5-difluorophenyl cyclohexyl trifluoromethanesulfonamide, trifluoromethanesulfonic acid, n-4-4-chlorobenzenesulfonyl-4-2,5-difluorophenyl-cyclohexyl-amide
11577204
N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
This item is not returnable. View return policy
677772-84-8
C19H17ClF5NO4S2
517.91
WDZVWDXOIGQJIO-UHFFFAOYSA-N
n-cis-4-4-chlorophenyl sulfonyl-4-2,5-difluorophenyl cyclohexyl-1,1,1-trifluoromethanesulfonamide, cyclohexyl sulfone-based compound, 32, n-4-4-chlorobenzene sulfonyl-4-2,5-difluorophenyl cyclohexyl trifluoromethanesulfonamide, trifluoromethanesulfonic acid, n-4-4-chlorobenzenesulfonyl-4-2,5-difluorophenyl-cyclohexyl-amide
11577204
N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

Description

γ-secretase inhibitor; attenuates amyloid plaque deposition

γ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
Quantity 10 mg
Formula Weight 517.92
Percent Purity >99%
Chemical Name or Material MRK 560

Safety and Handling

Recommended Storage Store at +4°C
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