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MSH2 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
$151.31
Specifications
| Antigen | MSH2 |
|---|---|
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-155-7650
|
Bethyl Laboratories, Inc
A300451AT |
20 μL |
Each of 1 for $151.31
|
|
|||||
Description
The recommended shelf life for this product is 1 year from date of receipt.
Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.Specifications
| MSH2 | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| COCA1, FCC1, HNPCC, HNPCC1 | |
| Between 1 and 50 | |
| Primary | |
| 4° C | |
| MSH2 |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse | |
| P43246, P43247 | |
| 17685, 4436 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
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