MTAP Antibody (MTAP/1813), DyLight 650, Novus Biologicals™

Catalog No.	Quantity
NB008653	0.1 mL

Catalog No. NB008653 Supplier Novus Biologicals Supplier No. NBP275731C

Description

Mouse Monoclonal Antibody

MTAP Monoclonal specifically detects MTAP in Human samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: MTAP
• Applications: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: MTAP/1813
• Conjugate: DyLight 650
• Dilution: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: 5'-methylthioadenosine phosphorylase, c86fus, EC 2.4.2.28, methylthioadenosine phosphorylase, MSAPMeSAdo phosphorylase, MTA phosphorylase, MTAPase, S-methyl-5'-thioadenosine phosphorylase
• Gene Symbols: MTAP
• Host Species: Mouse
• Immunogen: Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary) (Uniprot: Q13126)
• Purification Method: Protein A or G purified
• Quantity: 0.1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
• Target Species: Human
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG2b κ