MTM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9095	Proteintech Group Inc 139241AP150UL	150 μL

Description

Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.

Specifications

• Antigen: MTM1
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q13496, Q6AXQ4, Q9Z2C5
• Gene ID (Entrez): 17772, 288762, 4534
• Immunogen: MTM1 Fusion Protein Ag4940
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MTM1

• Concentration: 0.35 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CG2, CNM, MTM1, MTMX, Myotubularin, myotubularin 1, XLMTM
• Gene Symbols: Mtm1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody