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MUC1 Antibody (MUC1/967), PE/Cy7, Novus Biologicals™
SDP

Catalog No. N24785PECY7 Shop All R&D Systems Products
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N24785PECY7 0.1 mL
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Catalog No. N24785PECY7 Supplier Novus Biologicals Supplier No. NBP247885PECY7
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Description

Mouse Monoclonal Antibody

MUC1 Monoclonal specifically detects MUC1 in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen MUC1
Applications Flow Cytometry
Classification Monoclonal
Clone MUC1/967
Conjugate PE-Cyanine7
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Gene Symbols MUC1
Host Species Mouse
Immunogen Human milk-fat globule membranes (HMFGM) (Uniprot: P15941 )
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Cellular Markers, Extracellular Matrix, Inflammation, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 4582.0
Test Specificity This monoclonal antibody recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this monoclonal antibody is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the monoclonal antibody. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This monoclonal antibody reacts with both normal and malignant epithelia of various tissues including breast and colon.
Target Species Human
Content And Storage Store at 4°C in the dark. Do not freeze.
Isotype IgG1 κ
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