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  6. MUC1 Antibody (SPM492) - Azide and BSA Free, Novus Biologicals™

MUC1 Antibody (SPM492) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NBP247889A Shop All R&D Systems Products
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NBP247889A 0.1 mg
NBP247889B 0.2 mg
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Catalog No. NBP247889A Supplier Novus Biologicals Supplier No. NBP2478890.1MG
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Description

Mouse Monoclonal Antibody

MUC1 Monoclonal specifically detects MUC1 in Human, Mouse samples. It is validated for Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence, CyTOF-ready.

Specifications

Antigen MUC-1
Applications Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Classification Monoclonal
Clone SPM492
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry : 0.25 - 0.5 ug/million cells in 0.1ml, ELISA, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready
Formulation PBS with No Preservative
Gene Alias Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Gene Symbols MUC1
Host Species Mouse
Immunogen Breast Cancer Cell line ZR75-1
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cancer, Cellular Markers, Extracellular Matrix
Primary or Secondary Primary
Gene ID (Entrez) 4582
Test Specificity This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Target Species Human, Mouse
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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