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MUC3 Antibody (M3.1), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP247686A70 Shop All R&D Systems Products
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NP247686A70 0.1 mL
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Catalog No. NP247686A70 Supplier Novus Biologicals Supplier No. NBP247686AF750
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Description

Mouse Monoclonal Antibody

MUC3 Monoclonal specifically detects MUC3 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen MUC3
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone M3.1
Conjugate Alexa Fluor 750
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias MUC-3A, mucin 3, intestinal, mucin 3A, cell surface associated, mucin 3A, intestinal, mucin-3A
Gene Symbols MUC3A
Host Species Mouse
Immunogen A synthetic peptide of 35 amino acids, SIB35 (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS), which contains two of the MUC3 tandem repeats, coupled to KLH.
Purification Method Protein A or G purified
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 4584.0
Test Specificity It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This monoclonal antibody shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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