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Murine anti-PON1, Clone: KRJ1, ZeptoMetrix Corporation

Murine Monoclonal Antibody

Manufacturer:  ZeptoMetrix CorporationSupplier Diversity Partner 0801012

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Catalog No. 22-158-012


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Disclaimers:

For Research Use Only


Specifications

Description

PON1 (arylesterase/paraoxonase) is a polymorphic enzyme closely associated with high-density lipoproteins (HDL). It is located on chromosome 7 along with 2 other paraoxanase genes, PON2 and PON3. It is a 355 amino acid, 43kDa glycoprotein produced in the liver and secreted into the bloodstream. Gene polymorphisms occur in both coding and non-coding regions. Two major polymorphisms in the coding region are L55M and Q192R. Q192R polymorphisms result in three major functional phenotypes Q/Q, Q/R and RR. PON1 hydrolyses organophosphates and prevents the oxidation of low-density lipoproteins (LDL). It may inhibit the progression of atherosclerosis by inhibition of LDL oxidation. Levels of PON1 in serum vary among individuals and are decreased in chronic renal failure, liver cirrhosis, diabetes, peripheral neuropathy, and familial hypercholesterolemia.
Description & Specifications

Specifications

PON1
KRJ1
100μg in PBS. No preservatives added.
Murine
IgG1
100μg
Store at −10°C or below. Avoid freeze/thaw cycles. Thawed material may be stored at 4°C for short-term use.
Monoclonal
Western Blot
Unlabeled
Affinity Purified
Partially purified PON1 from human plasma
Protein G Purification
RUO
Primary
Human
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