Murine anti-PON1, Clone: KRJ1, ZeptoMetrix

Murine Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
22-158-012	ZeptoMetrix 0801012	100 μg
22-158-014	ZeptoMetrix 0801095	1 mg

Description

PON1 (arylesterase/paraoxonase) is a polymorphic enzyme closely associated with high-density lipoproteins (HDL). It is located on chromosome 7 along with 2 other paraoxanase genes, PON2 and PON3. It is a 355 amino acid, 43kDa glycoprotein produced in the liver and secreted into the bloodstream. Gene polymorphisms occur in both coding and non-coding regions. Two major polymorphisms in the coding region are L55M and Q192R. Q192R polymorphisms result in three major functional phenotypes Q/Q, Q/R and RR. PON1 hydrolyses organophosphates and prevents the oxidation of low-density lipoproteins (LDL). It may inhibit the progression of atherosclerosis by inhibition of LDL oxidation. Levels of PON1 in serum vary among individuals and are decreased in chronic renal failure, liver cirrhosis, diabetes, peripheral neuropathy, and familial hypercholesterolemia.

Specifications

• Antigen: PON1
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Immunogen: Partially purified PON1 from human plasma
• Primary or Secondary: Primary
• Content And Storage: Store at −10°C or below. Avoid freeze/thaw cycles. Thawed material may be stored at 4°C for short-term use.

• Clone: KRJ1
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Isotype: IgG1
• Purification Method: Affinity Purified

For Research Use Only