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MVP Antibody (1014), Novus Biologicals™
SDP

Catalog No. NBP24440001 Shop All R&D Systems Products
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NBP24440001 0.1 mg
NBP24440000 0.02 mg
NBP24440002 0.2 mg
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Catalog No. NBP24440001 Supplier Novus Biologicals Supplier No. NBP2444000.1MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

MVP Monoclonal specifically detects MVP in Human samples. It is validated for Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen MVP
Applications Flow Cytometry, SDS-Page, Immunofluorescence
Classification Monoclonal
Clone 1014
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias LRPVAULT1, Lung resistance-related protein, major vault protein
Gene Symbols MVP
Host Species Mouse
Immunogen Proteins precipitated from human breast cancer MCF-7 cells
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cancer
Primary or Secondary Primary
Gene ID (Entrez) 9961
Test Specificity Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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