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MVP Antibody (1032), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP247807A30 Shop All R&D Systems Products
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Catalog No. NP247807A30 Supplier Novus Biologicals Supplier No. NBP247807AF350
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Description

Mouse Monoclonal Antibody

MVP Monoclonal specifically detects MVP in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen MVP
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone 1032
Conjugate Alexa Fluor 350
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias LRPVAULT1, Lung resistance-related protein, major vault protein
Gene Symbols MVP
Host Species Mouse
Immunogen Proteins precipitated from human breast cancer MCF-7 cells
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 9961
Test Specificity Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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