MVP Antibody (1032), Alexa Fluor™ 532, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247807AF532

Catalog No. NP247807A32

Description

MVP Monoclonal specifically detects MVP in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

• Antigen: MVP
• Classification: Monoclonal
• Conjugate: Alexa Fluor 532
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: MVP
• Immunogen: Proteins precipitated from human breast cancer MCF-7 cells
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
• Content And Storage: Store at 4°C in the dark.

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: 1032
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
• Gene Alias: LRPVAULT1, Lung resistance-related protein, major vault protein
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Cancer
• Gene ID (Entrez): 9961.0
• Target Species: Human
• Isotype: IgG1 κ