Myopodin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-4915	Proteintech Group Inc 254531AP150UL	150 μL

Description

SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.

Specifications

• Antigen: Myopodin
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: D4A702, Q91YE8, Q9UMS6
• Gene ID (Entrez): 118449, 171024, 499702
• Immunogen: Myopodin Fusion Protein Ag22176
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SYNPO2

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Genethonin 2, Myopodin, synaptopodin 2, SYNPO2
• Gene Symbols: SYNPO2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody