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  7. NBI 35965 hydrochloride, Tocris Bioscience™

NBI 35965 hydrochloride, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl
This item is not returnable. View return policy
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

Description

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.
Quantity 50 mg
Formula Weight 437.79
Percent Purity >98%
Chemical Name or Material NBI 35965 hydrochloride

Safety and Handling

Recommended Storage : Store at Room Temperature