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Nbs1 Antibody (1D7), Novus Biologicals™
SDP

Catalog No. NB100221 Shop All R&D Systems Products
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NB100221 0.1 mL
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Catalog No. NB100221 Supplier Novus Biologicals Supplier No. NB100221
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Description

Mouse Monoclonal Antibody

Nbs1 Monoclonal specifically detects Nbs1 in Human, Mouse, Rat samples. It is validated for IF/IHC, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, KnockDown, Simple Western, Western Blot.

Specifications

Antigen Nbs1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, KnockDown, Simple Western, Western Blot
Classification Monoclonal
Clone 1D7
Concentration 1.0mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:500-1:3000, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Knockdown Validated
Gene Accession No. O60934
Gene Alias ATV, AT-V1, AT-V2, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBS, NBS1P95, nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex
Gene Symbols NBN
Host Species Mouse
Immunogen Nbs1 Antibody (1D7) was made to the complete coding region of the human p95/NBS1 expressed in E. coli.
Molecular Weight of Antigen 85 kDa
Purification Method Protein G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Breast Cancer, Cancer, Cell Cycle and Replication, Checkpoint signaling, Chromatin Research, DNA Double Strand Break Repair, DNA Repair, Homologous Recombination, Non homologous end joining, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 4683
Test Specificity Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nbs1 Antibody (1D7) recognizes the 95kDa NBS protein which contains a fork FHA head-associated domain that is adjacent to BRCT, a breast cancer C terminal domain, that has been implicated in protein-protein interactions. NBS is member of the Mre11/Rad50, p400 double-strand break repair complex involved in double-strand break repair and cell-cycle checkpoint functions.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1
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