Nbs1 Antibody (1D7), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NB100221

Catalog No. NB100221

Description

Nbs1 Monoclonal specifically detects Nbs1 in Human, Mouse, Rat samples. It is validated for Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Knockdown Validated.

Specifications

• Antigen: Nbs1
• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Dilution: Western Blot 1:500-1:3000, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Knockdown Validated
• Gene Alias: ATV, AT-V1, AT-V2, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBS, NBS1P95, nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex
• Host Species: Mouse
• Molecular Weight of Antigen: 85 kDa
• Quantity: 0.1 mL
• Research Discipline: Breast Cancer, Cancer, Cell Cycle and Replication, Checkpoint signaling, Chromatin Research, DNA Double Strand Break Repair, DNA Repair, Homologous Recombination, Non homologous end joining, Tumor Suppressors
• Gene ID (Entrez): 4683
• Target Species: Human, Mouse, Rat
• Form: Purified

• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, KnockDown
• Clone: 1D7
• Conjugate: Unconjugated
• Gene Accession No.: O60934
• Gene Symbols: NBN
• Immunogen: Nbs1 Antibody (1D7) was made to the complete coding region of the human p95/NBS1 expressed in E. coli.
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nbs1 Antibody (1D7) recognizes the 95kDa NBS protein which contains a fork FHA head-associated domain that is adjacent to BRCT, a breast cancer C terminal domain, that has been implicated in protein-protein interactions. NBS is member of the Mre11/Rad50, p400 double-strand break repair complex involved in double-strand break repair and cell-cycle checkpoint functions.
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG1

For Research Use Only