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Tocris Bioscience™ NDT 9513727
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Catalog No. 333350
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33-335-0 50 mg
33-331-0 10 mg
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Catalog No. 33-335-0 Supplier Tocris Bioscience™ Supplier No. 3333/50
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Description

Potent, selective human C5a receptor negative allosteric modulator (NAM)

Potent C5a receptor (C5aR) negative allosteric modulator (NAM) (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are > 10 μM). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC50 = 7.1 nM). Exhibits selectivity for primate and gerbil receptor over other species. Orally bioavailable.

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Chemical Identifiers

CAS 439571-48-9
Molecular Formula C36H35N3O4

Specifications

Quantity 50 mg
Formula Weight 573.68
Purity >98%
Molecular Weight (g/mol) 573.693
Chemical Name or Material NDT 9513727

Safety and Handling

Recommended Storage Store at +4°C
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