NDUFB8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 147941AP150UL

Catalog No. 50-172-9725

Description

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950, 000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyzes electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson′s disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

Specifications

• Antigen: NDUFB8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NDUFB8
• Gene Alias: ASHI, CI ASHI, Complex I ASHI, NDUFB8
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 293991, 4714, 67264
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.17 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O95169, Q9D6J5
• Gene Symbols: NDUFB8
• Immunogen: NDUFB8 Fusion Protein Ag6495
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG