NDUFB8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9725	Proteintech Group Inc 147941AP150UL	150 μL

Description

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950, 000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyzes electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson′s disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

Specifications

• Antigen: NDUFB8
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O95169, Q9D6J5
• Gene ID (Entrez): 293991, 4714, 67264
• Immunogen: NDUFB8 Fusion Protein Ag6495
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: NDUFB8

• Concentration: 0.17 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: ASHI, CI ASHI, Complex I ASHI, NDUFB8
• Gene Symbols: NDUFB8
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody