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NEDD4L Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7205800 Shop All Proteintech Group Inc Products
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50-172-8938 150 μL
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Catalog No. 50-172-8938 Supplier Proteintech Group Inc Supplier No. 136901AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody can recognize NEDD4-1 and NEDD4-2.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

Specifications

Antigen NEDD4L
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NEDD4L
Gene Accession No. Q8CFI0, Q96PU5
Gene Alias hNedd4 2, KIAA0439, NEDD4 2, NEDD4.2, NEDD4L, NEDL3, RSP5
Gene Symbols Nedd4l
Host Species Rabbit
Immunogen NEDD4L Fusion Protein Ag4565
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23327, 291553, 83814
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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