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Neural/Glial Antigen 2 (NG2) Mouse anti-Human, Clone: 9.2.27, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$96.25 - $226.00

Specifications

Antigen Neural/Glial Antigen 2 (NG2)
Clone 9.2.27
Target Species Human
Conjugate Unconjugated
Isotype IgG2a, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-245-580 Non-distribution product as customer accommodation.
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Invitrogen
14650480
25 μg Each for $96.25
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50-245-581 Non-distribution product as customer accommodation.
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Invitrogen
14650482
100 μg Each for $226.00
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Description

Description

Description: This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250 kDa N-linked glycoprotein and a >450 kDa proteoglycan. NG2 is present on the surface of >90% of maligt melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia. The 9.2.27 antibody has been reported to suppress melanoma tumor growth. Applications Reported: This 9.2.27 has been reported for use in flow cytometric analysis, immunoprecipitation, immunohistochemical staining of formalin-fixed paraffin embedded tissue (IHC-P), and immunocytochemical staining of fixed cells (ICC). Applications Tested: This 9.2.27 antibody has been tested by immunocytochemistry on methanol-fixed A375 cells at less than or equal to 10 µg/mL and by flow cytometric analysis on A375 cells at less than or equal to 0.125 µg/test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 µL.

Cell number should be determined empirically but can range from 10e5 to 10e8 cells/test. It is recommended that this antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered. A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human maligt melanoma cells.
Specifications

Specifications

Neural/Glial Antigen 2 (NG2)
Human
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
9.2.27
Unconjugated
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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