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Invitrogen™ NeuroD1 Recombinant Rabbit Monoclonal Antibody (JM11-10)
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Catalog No. PIMA532626
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PIMA532626 100 μL
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Catalog No. PIMA532626 Supplier Invitrogen™ Supplier No. MA532626
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
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Specifications

Antigen NeuroD1
Applications ChIP Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone JM11-10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene NEUROD1
Gene Accession No. Q13562, Q60867, Q64289
Gene Alias Basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; Beta2; beta-cell E-box transactivator 2; beta-cell E-box transcriptional activator 2; BHF1; BHF-1; bHLHa3; Class A basic helix-loop-helix protein 3; MODY6; neuro d1; Neurod; Neurod1; neurogenic differentiation 1; neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neuronal differentiation 1
Gene Symbols NEUROD1
Host Species Rabbit
Immunogen Synthetic peptide within Human NeuroD1 aa 1-44.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18012, 29458, 4760
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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