Tocris™ NIBR 189

Potent and selective EBI2 (GPR183) receptor antagonist

Manufacturer: Tocris™ 5203/10

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Catalog No. 52-031-0

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For Research Use Only


    Inhibitors NIBR 189
    Purity >99
    Molecular Weight 429.31
    Quantity 10mg
    Product Type NIBR 189

    Potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

    • Chemical Name: (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
    • Formula: C21H21BrN2O3
    • CAS Number: 1599432-08-2
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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