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Tocris Bioscience™ Niclosamide
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Catalog No. 407950
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

STAT3 inhibitor; also inhibits mTORC1 signaling

Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

Chemical Identifiers

CAS 50-65-7
Molecular Formula C13H8Cl2N2O4

Specifications

Quantity 50 mg
Formula Weight 325.99
Purity >99%
Molecular Weight (g/mol) 327.12
Chemical Name or Material Niclosamide

Safety and Handling

Recommended Storage Store at +4°C
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