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MP Biomedicals™ β-Nicotinamide Adenine Dinucleotide, Oxidized, MP Biomedicals™

Necessary for the catalytic reaction of certain enzymes. β-Nicotinamide Adenine Dinucleotide, Oxidized, MP Biomedicals is a pyridine nucleotide and biologically active form of nicotinic acid. β-NAD functions as an electron acceptor and occurs in

$37.70 - $88.50

Specifications

pH 2–4 (1% aq soln)
Format Powder
Molecular Weight 663.4 (anhyd.)
Storage Requirements −20°C. Store Desiccated
Purity ≥99%
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MP021600471 View Documents MP Biomedicals™
02160047.1
100mg Each for $37.70
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MP021600472 View Documents MP Biomedicals™
02160047.2
250mg Each for $58.10
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MP021600475 View Documents MP Biomedicals™
02160047.5
500mg Each for $88.50
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Description

Description

Many metabolites and enzymes of biological interest are present in tissues at low concentrations. With the use of β-NAD as a catalyst intermediate and several enzymes in a multistep system, known as enzyme cycling, much greater sensitivity for detection of these components is achieved. The reduced form, β-NADH, is fluorescent whereas β-NAD is not. This difference in fluorescence provides a sensitive fluorescent measurement of the oxidized or reduced pyridine nucleotides at concentrations down to 10-7 M.

  • Serves as a coenzyme of the dehydrogenases, especially in the dehydrogenation of primary and secondary alcohols
  • NAD usually acts as an electron acceptor, acting as a carrier for hydride ion, forming b-NADH which then serves as a hydrogen donor in the respiratory chain
    • Hydride ion is enzymatically removed from a substrate molecule by the action of dehydrogenases such as malic dehydrogenase and lactic dehydrogenase
    • Such enzymes catalyze the reversible transfer of a hydride ion from malate or lactate to b-NAD to form the reduced product, b-NADH
    • Unlike b-NAD which has no absorbance at 340nm, b-NADH absorbs at 340nm (EmM = 6.22)
    • The increase in absorbance at 340nm with the formation of b-NADH is the basis for measurement of activity of many enzymes
Specifications

Specifications

2–4 (1% aq soln)
663.4 (anhyd.)
≥99%
Powder
−20°C. Store Desiccated
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