NLRP2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 151821AP
DescriptionNALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|CLR19.9, NALP2, NBS1, NLRP2, PAN1, PYPAF2|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|NLRP2 Fusion Protein Ag7167|
|Antigen Affinity Chromatography|
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