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NLRX1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
$395.30
Specifications
| Antigen | NLRX1 |
|---|---|
| Concentration | 0.39 mg/mL |
| Applications | Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-556-660
|
Proteintech Group Inc
172151AP150UL |
150 μL |
Each of 1 for $395.30
|
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Description
NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.Specifications
| NLRX1 | |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse | |
| IgG | |
| -20°C |
| 0.39 mg/mL | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Antigen Affinity Chromatography | |
| Antibody |
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