Invitrogen™ NOD2 Monoclonal Antibody (2D9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA116611

Catalog No. AMPA6611

Description

The target sequence has 92% sequence homology with primate.

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

Specifications

• Antigen: NOD2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q8K3Z0, Q9HC29
• Gene Symbols: NOD2
• Immunogen: Recombinant human NOD2 protein corresponding to residues 28-301.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 2D9
• Conjugate: Unconjugated
• Gene: NOD2
• Gene Alias: ACUG; BLAU; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; CD; CLR16.3; F830032C23Rik; IBD1; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; Nlrc2; NOD 2; NOD2; NOD-2; NOD2 protein; NOD2B; NOD-like receptor C2; nucleotide binding oligomerization domain containing 2; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; nucleotide-binding oligomerization domain-containing protein 2; PSORAS1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 257632, 64127
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid